Nutrition, host metabolism and the antimicrobial response to enteric infection in the neonatal host

Graphical abstract for Project A01

Early infection with the human enteropathogen Salmonella affects the fetal-neonatal transition of the intestinal epithelium. Such infections can therefore influence nutrient digestion, substrate absorption, energy metabolism and microbiota establishment, as well as antimicrobial host defense activation. 

In this project, we explore molecular mechanisms of these effects and the resulting influence of altered substrate availability on mucosal antimicrobial properties.