Long-lasting consequences of early-life influenza A virus infection for the tissue-resident memory T cell niche and susceptibility to secondary infections
In this project, we investigate the long-lasting consequences of early-life influenza A virus (IAV) infections in terms of adaptation of the lung microenvironment and susceptibility to secondary bacterial infections later in life.
In particular, we examine how IAV infections alter lung-resident immune cell populations. These alterations may contribute to the formation of tissue-resident memory T cell niches and affect the response to secondary pneumococcal infections in adulthood.
Team
Publications
Isolation of Alveolar Type II Epithelial Cells from Neonatal, Juvenile, and Adult Murine Lungs Adaptable to Infectious Experimental SettingsGrimpe, P., Melcher, L., Gröbe, L., Hühn, J., Boehme, J. D., Bruder, D 2025 Journal of Visualized Experiments
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Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a humanized mouse modelJustine Smout, Till Robin Lesker, Lisa Hoenicke, Diego Ortiz, Mangge Zou, Friederike Kruse, Sabine Pirr, Maike Willers, Christoph Härtel, Christine Falk, Natalia Torow, Dorothee Viemann, Till Strowig, Jochen Huehn
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Epigenetic changes and serotype-specific responses of alveolar type II epithelial cells to Streptococcus pneumoniae in resolving influenza A virus infectionBoehme JD, Jeron A, Schultz K, Melcher L, Schott K, Gelmez E, Kröger A, Stegemann-Koniszewski S, Bruder D 2025 Cell Communication and Signaling
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Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodesMangge Zou, Joern Pezoldt, Juliane Mohr, Lars Philipsen, Andrea Leufgen, Vuk Cerovic, Carolin Wiechers, Marina Pils, Diego Ortiz, Lianxu Hao, Juhao Yang, Michael Beckstette, Aline Dupont, Mathias Hornef, Petra Dersch, Till Strowig, Andreas J. Müller, Jens Raila, Jochen Huehn 2024 Cell Reports
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Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthoodVogel K, Arra A, Lingel H, Bretschneider D, Prätsch F, Schanze D, Zenker M, Balk S, Bruder D, Geffers R, Hachenberg T, Arens C, Brunner-Weinzierl MC 2023 Nature Communications
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