Role of placenta-derived peptide PIF in perinatal immune cell regulation
In this project, we exploit methodological knowledge of intravital imaging and leukocyte recruitment in the fetus to investigate the mechanistic role of the peptide Preimplantation Factor (PIF) in the regulation of maternal and fetal immune cells. The project evaluates the impact of PIF on fetal immune cell programming and study the regulation of PIF itself during pregnancy.
Team
Publications
Neonatal neutrophils exhibit reduced NLRP3 inflammasome activationLou Martha Wackerbarth, Sonja Birke Seifert, Matteo Napoli, Ina Rohwedder, Thomas Vogl, Christoph Scheiermann, Thomas Kolben, Claudia Nussbaum, Monika Pruenster, Roland Immler, Markus Sperandio 2024 Journal of Leukocyte Biology
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CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IVRoland Immler, Katrin Nussbaumer, Axel Doerner, Omar ElBounkari, Silke Huber, Janine Abisch, Matteo Napoli, Sarah Schmidt, Andreas Margraf, Monika Pruenster, Ina Rohwedder, Baerbel Lange-Sperandio, Marcus A. Mall, Renske de Jong, Caspar Ohnmacht, Juergen Bernhagen, David Voehringer, Jamey D.Marth, David Frommhold, and Markus Sperandio 2024 PNAS
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E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formationMonika Pruenster, Roland Immler, Jonas Roth, Tim Kuchler, Thomas Bromberger, Matteo Napoli, Katrin Nussbaumer, Ina Rohwedder, Lou Martha Wackerbarth, Chiara Piantoni, Konstantin Hennis, Diana Fink, Sebastian Kallabis, Tobias Schroll, Sergi Masgrau-Alsina, Agnes Budke, Wang Liu, Dietmar Vestweber, Christian Wahl-Schott, Johannes Roth, Felix Meissner, Markus Moser, Thomas Vogl, Veit Hornung, Petr Broz & Markus Sperandio 2023 Nature Immunology
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Perinatal development of innate immune topology.Philipp Henneke, Katrin Kierdorf, Lindsay J Hall, Markus Sperandio, Mathias Hornef 2021 eLife
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