Development and functional implications of circadian leukocyte dynamics in early life
Our project elucidates how circadian rhythms in myeloid cell function and trafficking are established in the perinatal period. We seek to define the time window during which these rhythms develop and explore their relevance in disease.
The project is based on our previous discoveries concerning steering of leukocyte functions by circadian rhythms. In particular, we examine mechanisms that govern these rhythms in the fetus just before birth and in the neonate. We also explore the relevance of these rhythms in a neonatal bacterial sepsis model.
Team
Publications
Maternal rhythms suppress neonatal inflammation2024 Nature Metabolism
|
A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogenyRohwedder I, Wackerbarth LM, Heinig K, Ballweg A, Altstätter J, Ripphahn M, Nussbaum C, Salvermoser M, Bierschenk S, Straub T, Gunzer M, Schmidt-Supprian M, Kolben T, Schulz C, Ma A, Walzog B, Heinig M, Sperandio M. 2023 JCI Insight
|
The circadian immune systemChen Wang, Lydia Kay Lutes, Coline Barnoud, Christoph Scheiermann 2022 Science Immunol
|
Perinatal development of innate immune topology.Philipp Henneke, Katrin Kierdorf, Lindsay J Hall, Markus Sperandio, Mathias Hornef 2021 eLife
|