Development and functional implications of circadian leukocyte dynamics in early life

Graphical abstract for Project B07

Our project elucidates how circadian rhythms in myeloid cell function and trafficking are established in the perinatal period. We seek to define the time window during which these rhythms develop and explore their relevance in disease.

The project is based on our previous discoveries concerning steering of leukocyte functions by circadian rhythms. In particular, we examine mechanisms that govern these rhythms in the fetus just before birth and in the neonate. We also explore the relevance of these rhythms in a neonatal bacterial sepsis model.