Effects of maternal hyperlipidemia on embryo-derived macrophages and perinatal immune development
In this project, we analyze how maternal hyperlipidemia affects embryonic macrophages – the cell type at the core of the project leader's research interests.
Tools include temporal control of metabolic disease activity during pregnancy with low density lipoprotein receptor anti-sense oligonucleotides, cross fostering experiments, and long-term phenotyping of prenatally exposed mice. Furthermore, we investigate study human placental pathology with a focus on embryo-derived Hofbauer macrophages and maternal decidua macrophages.
Team
Publications
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammationPekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K. 2023 Immunity
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Monocyte signature as a predictor of chronic lung disease in the preterm infantWindhorst Anita C., Heydarian Motaharehsadat, Schwarz Maren, Oak Prajakta, Förster Kai, Frankenberger Marion, Gonzalez Rodriguez Erika, Zhang Xin, Ehrhardt Harald, Hübener Christoph, Flemmer Andreas W., Hossain Hamid, Stoeger Tobias, Schulz Christian, Hilgendorff Anne 2023 Frontiers in Immunology
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