The role of S100-alarmins in the perinatal development of respiratory immunity
S100-alarmins are endogenous factors that tune systemic and gut immunity after birth, thereby ensuring immune adaptation to the environment. Our project explores the role of S100A8/A9 in the perinatal development of lung and airway immunity.
We focus on neonatal and long-term programming of epithelial cells and cross-talk with professional immune cells, platelets and the vascular system. We also elucidate the cellular source of S100A8/A9 in the amniotic fluid by investigating non-immune cells in the lung.
Team
Publications
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammationPekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K. 2023 Immunity
|
Meconium Microbiome of Very Preterm Infants across GermanyJonas Klopp, Pamela Ferretti, Claudius U. Meyer, Katja Hilbert, Annette Haiß, Janina Marißen, Philipp Henneke, Hannes Hudalla, Sabine Pirr, Dorothee Viemann, Michael Zemlin, Sofia Kirke Forslund, Christoph Härtel, Peer Bork, Stephan Gehring, Thea Van Rossum, and the PRIMAL Consortium and Vincent B. Young |
S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and InfantsWillers, M., Ulas, T., Völlger, L., Vogl, T., Heinemann, A. S., Pirr, S., Pagel, J., Fehlhaber, B., Halle, O., Schöning, J., Schreek, S., Löber, U., Essex, M., Hombach, P., Graspeuntner, S., Basic, M., Bleich, A., Cloppenborg-Schmidt, K., Künzel, S., … Viemann, D. 2020 Gastroenterology
|