The role of S100-alarmins in the perinatal development of respiratory immunity

Graphical abstract for Project A03

S100-alarmins are endogenous factors that tune systemic and gut immunity after birth, thereby ensuring immune adaptation to the environment. Our project explores the role of S100A8/A9 in the perinatal development of lung and airway immunity.

We focus on neonatal and long-term programming of epithelial cells and cross-talk with professional immune cells, platelets and the vascular system. We also elucidate the cellular source of S100A8/A9 in the amniotic fluid by investigating non-immune cells in the lung.



Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation

Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K.