Immune trajectories defining early lung development in newborn infants

Graphical abstract for Project A08

We combine complementary expertise on human and mouse neonatal lung development and on transcriptomics in lung cells. Using this combined expertise, we study consequences of oxygen therapy and of mechanical forces on the interaction of lung immune and non-immune cells.

We explore mechanisms underlying innate immune cell differentiation in chronic lung disease of preterm infants. We uses an existing cohort of preterm infants including longitudinal biomaterial, and a new small prospective cohort.