Perinatal fate decisions of macrophages in protected tissues
This project expands our previous work on myeloid cell development starting in embryonic life by delineating patterns of ontogeny, underlying transcriptional programs and molecular signals driving the perinatal development of parenchymal (pMφ) as opposed to perivascular Mφ (periMφ). The project focuses on tissues that are largely protected from direct microbial contact (brain, heart, kidney) and exploits novel fate mapping systems, single-cell profiling and cell-specific mutants to define pre- to postnatal check points, tissue-specific niches and cues that modify the fate and function of pMφ and periMφ.
Team
Publications
Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiotaDavid Obwegs, Alexander Oschwald, Lara M. Koetter, Cylia Crisand, Sidney Doerr, Kerstin Bruder, Solveig Runge, Nisreen Ghanem, Vidmante Fuchs, Marleen Eckert, Christian Koengeter, Anna- Maria Schaffer, Lukas Amann, Sophia Papaioannou,Tim Rollenske, Julia Kolter, Daniel Erny, Marco Prinz, Susana Minguet, Wolfgang W. Schamel, Philipp Henneke, Stephan P. Rosshart, Katrin Kierdorf, Sagar 2026 Science Advances
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Bacterial infection reshapes monocyte and macrophage ontogeny at the CNS bordersGres V, Lohrmann F, Fuchs V, Neuber J, Moghadam ZM, Lösslein AK, Bosch LFP, Figueiral-Martins T, Baasch S, Obwegs D, Monaco G, Henschel J, Knobeloch KP, Prinz M, Jung S, Kierdorf K, Sagar, Kolter J, Erny D, Henneke P. 2026 Science Immunology
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A transcriptomic microglia taxonomy across mouse and human pathologiesChhatbar C, Sankowski R, Schulz M, Shimizu T, Schwabenland M, Staszewski O, Scheiwe C, Nessler S, Borst K, Dumas AA, Trost E, Berchtold D, Brandão W, Mossad O, Dalmau Gasull A, Frosch M, Erny D, Diebold M, Guffart E, Ternka K, Guranda M, Vinnakota JM, Friesen M, Ouk K, Waltl I, LaMorte M, Hammond TR, Di Liberto G, Vincenti I, Kreutzfeldt M, Mughrabi IT, Al-Abed Y, Blank T, Meyer-Luehmann M, Crow YJ, Hagen N, Ofengeim D, Zeiser R, Kettwig M, Gärtner J, Meisel A, Schwemmle M, Kalinke U, Beck J, Bengsch B, Thimme R, Butovsky O, Seredenina T, Ransohoff RM, Quintana FJ, Kierdorf K, Merkler D, Stadelmann C, Priller J, Prinz M. 2026 Nature Immunology
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Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulationFliegauf M, Levard D, Cardamone F, Frosch M, Kuhn S, Sankowski R, Provinciali M, Dumas AA, Dalmau Gasull A, Aktories P, Oschwald A, Schwabenland M, Scholz R, Beyer MD, Neher JJ, Kollefrath M, Baltas D, Reichardt W, von Elverfeldt D, Vivien D, Cupovic J, Iovino N, Rubio M, Amann L, Prinz M. 2026 Nature Immunology
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Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface.Petry P, Oschwald A, Merkt S, Dinh TJ, Andrieux G, Crisand C, Botterer H, Nent E, Paterson N, Havermans M, Sankowski R, Schilling O, Boerries M, Amann L, Groß O, Schlitzer A, Prinz M, Lämmermann T, Kierdorf K. 2026 Developmental Cell
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Microglia-neuron crosstalk through Hex-GM2-MGL2 maintains brain homeostasis |
Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surfacePetry P, Oschwald A, Merkt S, Dinh TJ, Andrieux G, Crisand C, Botterer H, Nent E, Paterson N, Havermans M, Sankowski R, Schilling O, Boerries M, Amann L, Groß O, Schlitzer A, Prinz M, Lämmermann T, Kierdorf K 2025 Developmental Cell
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The niche matters: origin, function and fate of CNS-associated macrophages during health and diseaseAdrià Dalmau Gasull, Martina Glavan, Sai K. Reddy Samawar, Kishan Kapupara, Joe Kelk, Marina Rubio, Stefano Fumagalli, Lydia Sorokin, Denis Vivien & Marco Prinz 2024 Acta Neuropathologica
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Microglia out of place—mapping macrophages across the developing human bodyRoman Sankowski & Marco Prinz 2023 Cellular & Molecular Immunology volume
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Multiomic spatial landscape of innate immune cells at human central nervous system bordersRoman Sankowski, Patrick Süß, Alexander Benkendorff, Chotima Böttcher, Camila Fernandez-Zapata, Chintan Chhatbar, Jonathan Cahueau, Gianni Monaco, Adrià Dalmau Gasull, Ashkan Khavaran, Jürgen Grauvogel, Christian Scheiwe, Mukesch Johannes Shah, Dieter Henrik Heiland, Oliver Schnell, Filiz Markfeld-Erol, Mirjam Kunze, Robert Zeiser, Josef Priller & Marco Prinz 2023 Nature Medicine
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Metabolic rewiring tunes dermal macrophages in staphylococcal skin infectionForde AJ, Kolter J, Zwicky P, Baasch S, Lohrmann F, Eckert M, Gres V, Lagies S, Gorka O, Rambold AS, Buescher JM, Kammerer B, Lachmann N, Prinz M, Groß O, Pearce EJ, Becher B, Henneke P. 2023 Science Immunol
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Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment |