Perinatal fate decisions of macrophages in protected tissues

Graphical abstract for Project B0

This project expands our previous work on myeloid cell development starting in embryonic life by delineating patterns of ontogeny, underlying transcriptional programs and molecular signals driving the perinatal development of parenchymal (pMφ) as opposed to perivascular Mφ (periMφ). The project focuses on tissues that are largely protected from direct microbial contact (brain, heart, kidney) and exploits novel fate mapping systems, single-cell profiling and cell-specific mutants to define pre- to postnatal check points, tissue-specific niches and cues that modify the fate and function of pMφ and periMφ.