Immune trajectories defining early lung development in newborn infants
We combine complementary expertise on human and mouse neonatal lung development and on transcriptomics in lung cells. Using this combined expertise, we study consequences of oxygen therapy and of mechanical forces on the interaction of lung immune and non-immune cells.
We explore mechanisms underlying innate immune cell differentiation in chronic lung disease of preterm infants. We uses an existing cohort of preterm infants including longitudinal biomaterial, and a new small prospective cohort.
Team
Publications
Paired Airway and Blood Multiomics Defines Coordinated Immune Adaptation Across the Airway–Blood Axis in Preterm InfantsSafwen Kadri, Zhenda Wang, Claudia Nussbaum, Johannes B. Müller-Reif, Alicia-Sophie Schebesta, Rizqah Kamies, Brittany T. Rupp, Tanja Seegmüller, Caroline Johansson, Maarten Weiß, Axel Heep, Eduard Malik, Kai Förster, Andreas Flemmer, Mapping the Inhalation Interface Network (MPII-NET), Karin Loser, Herbert B. Schiller, Kevin Matthew Byrd, Anne Hilgendorff 2026 MedRxiv
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Artificial Intelligence-Supported Colorimetric Multibiomarker Sensor to Enable Critical Neonatal MonitoringAlejandra Castelblanco, Elisabetta Ruggeri, Giusy Matzeu, Motaharehsadat Heydarian, Kai Foerster, Ahmed Bahnasy, Andreas Flemmer, Julia A. Schnabel, Benjamin Schubert, Fiorenzo G. Omenetto and Anne Hilgendorff 2026 ACS Sensors
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A biomimetic miniaturized in vitro model to target early markers of neonatal pulmonary vascular injuryHeydarian M, Doryab A, Henao J, Schubert B, Schmid O, Hilgendorff A 2026 American Journal of Physiology
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Lung MRI scoring reveals persistence of emphysema-like changes in lungs of infants born preterm at (pre)school ageFörster K, Strobl K, Kindt A, Häfner F, Schubert B, Heinen F, Flemmer AW, Steffinger D, Dietrich O, Stoecklein S, Brinkmann F, Hilgendorff A. 2025 ERJ Open Research
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Monocyte signature as a predictor of chronic lung disease in the preterm infantWindhorst Anita C., Heydarian Motaharehsadat, Schwarz Maren, Oak Prajakta, Förster Kai, Frankenberger Marion, Gonzalez Rodriguez Erika, Zhang Xin, Ehrhardt Harald, Hübener Christoph, Flemmer Andreas W., Hossain Hamid, Stoeger Tobias, Schulz Christian, Hilgendorff Anne 2023 Frontiers in Immunology
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